Causes of Prostate Cancer – Everyone Should Know

Causes of Prostate Cancer – Everyone Should Know

The Prostate gland is located beneath the bladder and in front of the rectum in men. The main function of the prostate gland is to produce some fluids in semen and it also controls urine. It is exclusive for men. If diagnosed early, it is curable. It is ideal to have regular screening of the prostate gland so that the cancer could be detected earlier before it spreads to other parts of the body. It is curable if found in the early stages.

Symptoms For Prostate Cancer:

Though there are no symptoms at early stages. In case, if you find the following symptoms, it is ideal to get in touch with the Best cancer hospital in India:

Frequent urge for urination including at night
When you face difficulty in commencing and maintaining urination
Presence of blood in the urine
Painful urination as well as less common ejaculation
Difficulty in achieving or maintaining the erection

In case of advanced stages, the following symptoms will persist:

Bone pain in the spine, pelvis, ribs, and femur.
Bone fractures

Risks For Prostate Cancer:

The following risk factors are associated with It:

Genetic factors
Agent orange

When you are diagnosed with itr, you can go for Prostate Cancer Treatment from any leading hospital.

Causes for Prostate Cancer

The exact causes of it is unknown. Researchers feel some of the risk factors given above could cause prostate cells to become cancer.

When there are changes in the DNA of a normal prostate cell, it is caused. The genes are made up of the chemical called DNA found in our cells. Our cells functions are controlled by genes. DNA is got from our parents and we look like them. However, DNA affects more than just how we look.

Some genes control the growth of the cells, divides, and also stay alive. Those genes are called oncogenes. Tumor suppressor Genes control the growth of cells, repair mistakes in DNA, and cause cells to die at the right time. Mutations of DNA which turn into oncogenes and turns off tumor suppressor genes cause cancer. DNA changes could be inherited from your parents or can be acquired during your lifetime.

Inherited Gene Mutations

DNA mutations are passed from one generation to another and are found in all the cells in the body. These are inherited. Nearly 5-10% of prostate cancer is caused by inherited genes. Such cancers are called hereditary cancer. Various inherited genes are linked to hereditary prostate cancer including the following:
RNASEL (formerly HPC1): The major function of this tumor suppressor is to help cells die when something goes wrong inside them. This gene’s inherited mutations will allow abnormal cells to live for a longer time and this causes prostate cancer.

BRCA1 and BRCA2: These genes which are tumor suppressors normally help repair mistakes in the DNA of a cell (or cause the cell to die if it cannot be fixed). Inherited mutations of these genes result in breast cancer as well as ovarian cancer in women. But when there are changes in it (especially BRCA2), accounts for a small number of prostate cancer.

DNA mismatch repair genes (like MSH2 and MLH1): These genes normally help in fixing the mistakes in DNA that are made when a cell divides into two new cells. Cells need to make a copy of their DNA when they divide. Inherited mutations of this cell cause Lynch syndrome in Men and are at increased risk of colorectal, prostate and some other cancers.

HOXB13: This is very important for the development of the prostate gland. Mutations in this gene are linked with early-onset prostate cancer (prostate cancer diagnosed at a young age) in some families. Fortunately, it is very rare.

Acquired Gene Mutations

During a person’s lifetime, some gene mutations will happen which will not be passed on to children. These changes are found only in cells that hail from the original mutated cell. These are called acquired mutations. Most of the prostate cancer develops during a man’s life rather than inherited.

From some research, it is found out that men with high levels of another hormone i.e. insulin-like growth factor-1 (IGF-1) are prone to prostate cancer. However, such links are not found in various studies. Further researches are to be done to make sense of these findings.

As seen in the risk factors for  Cancer, some studies show that inflammation in the prostate might cause it. The theory says that inflammation will lead to cell DNA damage. This will contribute to a normal cell becoming the cancerous cell. However, more researches should be done to prove this.

When you get in touch with the Best cancer hospital in India , they will plan your Prostate Cancer Treatment which also differs from one person to another.

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